From: Subject: Engineering relief - The Whig Standard - Ontario, CA Date: Mon, 27 Feb 2012 11:38:13 -0500 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_007D_01CCF544.4A000BC0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.6157 This is a multi-part message in MIME format. ------=_NextPart_000_007D_01CCF544.4A000BC0 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.thewhig.com/ArticleDisplay.aspx?e=3483710 =EF=BB=BF Engineering relief - The Whig Standard - = Ontario, CA <= !-- //KS LightBox -->

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Danielle VandenBrink/The Whig-Standard Dr. = Lauren=20 Flynn, a chemical engineer at Queen's University, has developed a new = process to=20 transform human fat into a soft-tissue substitute that can be used to = regenerate=20 soft tissue in patients, including those who have experienced traumatic = injuries=20 or have underwent lumpectomies.

Engineering relief

By Danielle VandenBrink/The = Whig-Standard

Posted 12 hours ago

A process developed by a Queen=E2=80=99s = University researcher could=20 lead to a breakthrough in healing from traumatic injuries and = disfiguring=20 surgeries.

Dr. Lauren Flynn, a chemical engineer, has successfully transformed = human fat=20 =E2=80=94 discarded during surgery =E2=80=94 into a soft-tissue = substitute that can potentially=20 be used in repairing or replacing missing or damaged tissue.

This includes people who have suffered burns, traumatic injury, = congenital=20 defects or tumour removal, such as women who have undergone a lumpectomy = due to=20 breast cancer.

=E2=80=9CI was really motivated by the need for this type of = substitute,=E2=80=9D Flynn said=20 during an interview with the Whig-Standard on Saturday. =E2=80=9CI could = see it wasn=E2=80=99t=20 being addressed, so it was something I was interested in = researching.=E2=80=9D

Flynn began her research in the Department of Chemical Engineering at = Queen=E2=80=99s=20 in 2007 after obtaining a doctorate from the University of Toronto in = chemical=20 and biomedical engineering.

In a laboratory in Kingston General Hospital, Flynn and a research = team work=20 with 20- to 25-gram pieces of fat most commonly discarded during = reduction=20 surgeries, such as liposuction.

Researchers mince the fat and remove cells and other components from = it that=20 could provoke an immune response in the animals. The result is a natural = material that can be made into various forms, called = =E2=80=9Cscaffolding.=E2=80=9D

=E2=80=9CIt=E2=80=99s just a very flexible platform,=E2=80=9D Flynn = said, explaining the scaffolding=20 has been produced in the form of a sheet and very small = Styrofoam-looking balls=20 designed to be implanted in the body. =E2=80=9CStarting with something = that nobody=20 wanted, we can make all different constructs from.=E2=80=9D

In pre-clinical trials, Flynn has implanted the scaffolding into mice = and=20 rats in hopes of stimulating healthy fat regeneration.

The results have been promising, she said.

=E2=80=9CIf we implant it into an animal, we start seeing healthy = fat, which I=E2=80=99ve=20 never seen with any other type of material before,=E2=80=9D she said. =

The technology has also been combined with stem = cells, which=20 help to =E2=80=9Ckick start=E2=80=9D the process, she said.

=E2=80=9C(Stem cells) secrete different factors that help promote = blood vessel=20 formation, they help minimize inflammation and they just create a better = environment within the host,=E2=80=9D she said.

Because it is natural material, Flynn said it degrades over time and = the body=20 slowly replaces it with healthy tissue. It also won=E2=80=99t provoke a = negative immune=20 response, as seen with other foreign types of materials, she said.

Flynn said she hopes the technology will eventually be used to in=20 reconstructive surgeries =E2=80=94 ultimately giving people back what = they lost.

=E2=80=9CWomen who (undergo) a lumpectomy now, (doctors) = don=E2=80=99t do anything,=E2=80=9D she=20 said. =E2=80=9CThey essentially remove a good portion of the tissue and = then it just=20 contracts. So you end up with a lot of scarring, which can be painful, = and=20 deformity, which is obviously going to affect your quality of life.

=E2=80=9CThese are the types of procedures that we=E2=80=99re = initially targeting and I think=20 as we further develop we=E2=80=99re looking at it for further = applications.=E2=80=9D

In the case of a breast, Flynn said in theory engineers could create = a=20 scaffold large enough to replace tissue that was lost during a = lumpectomy. Once=20 implanted in the body, it would eventually be replaced with healthy = tissue,=20 creating a new breast, she said.

=E2=80=9C(Surgeons) would immediately put in a scaffold that was = shaped to the volume=20 that you lost,=E2=80=9D she said. =E2=80=9CSo you wouldn=E2=80=99t end = up with that scarring =E2=80=A6 and=20 eventually maintain your shape.=E2=80=9D

Recently, Flynn was awarded a grant from Mars, a Toronto-based = organization=20 that funds research in the medical industry. The $192,500 grant will = allow Flynn=20 to advance the technology in testing in larger animals, namely pigs.

She hopes to have that testing started within the year, she said. =

Flynn and researchers are also looking ahead to clinical trials on = humans,=20 which she said could begin in as soon as five years.

=E2=80=9CThe goal is to work towards what=E2=80=99s going on in = humans,=E2=80=9D she said, =E2=80=9Cso we=E2=80=99re=20 selecting the data we need to ensure that it=E2=80=99s going to be safe = and effective=20 for people.=E2=80=9D

She said the response from the medical community has been positive. =

=E2=80=9CI think part of it is, it=E2=80=99s not been an extensively = studied area, it=E2=80=99s=20 something that=E2=80=99s sort of new,=E2=80=9D she said. =E2=80=9CThere = aren=E2=80=99t that many people,=20 especially in Canada, studying adipose (fat)-derived stem cells and = these=20 scaffolds that we=E2=80=99ve developed is something completely new.

=E2=80=9CI think people can see the potential and we=E2=80=99re = really excited.=E2=80=9D

Because cosmetic surgery is on the rise, Flynn said using discarded = fat makes=20 sense for reconstructing soft tissue.

=E2=80=9CIt=E2=80=99s something that is pretty easily = accessible,=E2=80=9D she said. =E2=80=9C(Human fat) is=20 a very rich source of stem cells. For me, it=E2=80=99s one of the most = logical sources=20 to obtain cells for these cell-based therapies because most people have = some=20 that they=E2=80=99re willing to part with.=E2=80=9D

Fat is also more abundant than stem cells from other sources, such as = umbilical cord or bone marrow, making it more accessible, she said.

Although the fat would be thrown away, Flynn said hospitals are = required to=20 ask patients permission to use the fat.

Recently, Flynn said she=E2=80=99s accompanied surgeons when asking = patient=E2=80=99s=20 permission, and said the response has been positive.

=E2=80=9CWhen they see that it=E2=80=99s something that would = normally be discarded most=20 people are willing,=E2=80=9D she said, =E2=80=9Cespecially when they = think it=E2=80=99s going to help=20 someone.

=E2=80=9CWe=E2=80=99re just trying to create an ultimate product or = outcome that will improve=20 people=E2=80=99s lives.=E2=80=9D

dvandenbrink@thewhig.com

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$("#"+t+c).html( $("up", xml).text() + " Thumbs Up | " + $("down", = xml).text() + " Thumbs Down"); $("#vbtn"+c).html( "" ); } else if ( $("return", xml).text() =3D=3D 1 ) { //alert("Already Voted!"); $("#tooltip").hide(); $("#"+t+c).html( $("up", xml).text() + " Thumbs Up | " + $("down", = xml).text() + " Thumbs Down"); $("#vbtn"+c).html( "" ); } else if ( $("return", xml).text() =3D=3D 3 ) { alert("Missing a value"); } else { alert("Must be logged in to vote"); } } }); } function Save(a, b) { $.ajax({ url: '/Account/Clipboard/Clipboard.asmx/AddToClipboard', type: 'POST', dataType: 'xml', =20 data: "a=3D"+a+"&b=3D"+b, timeout: 10000, error: function(request, errtype){ alert(request.responseText); alert('Error saving - please try again later!'); }, success: function(xml){ // do something with xml =20 if ( $("int", xml).text() =3D=3D 0 ) { alert("Saved to Clipboard\nYour clipboard can be found under = Account > My Clipboard"); } else if ( $("int", xml).text() =3D=3D 1 ) { //alert("You must be logged in to save an article."); tb_show('Login', = '/Remote/Login.aspx?continue=3D%2FRemote%2Fdone%2Easpx%3Fa%3D'+a+ = '%26b%3D'+b+'&TB_iframe=3Dtrue&height=3D300&width=3D500',false); } else if ( $("int", xml).text() =3D=3D 2 ) { alert("Article already saved to Clipboard\nYour clipboard can be = found under Account > My Clipboard"); } else { alert("Unknown error (" + $("int", xml).text() + ") occurred. = Please try again later."); } } }); } function Save2(a, b) { $.ajax({ url: '/Account/Clipboard/Clipboard.asmx/AddToClipboard', type: 'POST', dataType: 'xml', =20 data: "a=3D"+a+"&b=3D"+b, timeout: 10000, error: function(request, errtype){ alert(request.responseText); alert('Error saving - please try again later!'); }, success: function(xml){ // do something with xml =20 if ( $("int", xml).text() =3D=3D 0 ) { alert("Article saved"); top.tb_remove(); } else if ( $("int", xml).text() =3D=3D 1 ) { //alert("You must be logged in to save an article."); //tb_show('Login', = '/Remote/Login.aspx?continue=3D%2FRemote%2Fdone%2Easpx%3Fa%3D'+a+ = '%26b%3D'+b+'&TB_iframe=3Dtrue&height=3D300&width=3D500',false); } else if ( $("int", xml).text() =3D=3D 2 ) { alert("Article already saved."); top.tb_remove(); } else { alert("Unknown error (" + $("int", xml).text() + ") occurred. = Please try again later."); top.tb_remove(); } } }); } function=20 WriteDate(){ var today =3D new Date(); var months =3D new Array( "January", "February", "March", "April",=20 "May", "June", "July", "August", "September",=20 "October", "November", "December" ); var m =3D today.getMonth(); var d =3D today.getDate();=09 var y =3D today.getFullYear();=09 document.write(months[m] + " " + d + ", " + y); } function np2TB_toggle(linkName) { var mWidth =3D 154; var shift =3D -109; if($.browser.msie) { if($.browser.version =3D=3D "8.0") mWidth =3D 156; else mWidth =3D 155; } else if($.browser.safari) { shift =3D -108; mWidth =3D 153; $("#np2TBdelete").css("width", mWidth + "px"); $("#np2TBpromote").css("width", mWidth + "px"); } else if($.browser.opera) { mWidth =3D 153; $("#np2TBdelete").css("width", mWidth + "px"); $("#np2TBpromote").css("width", mWidth + "px"); } =20 =20 if(linkName =3D=3D "np2TBpromote") { if($("#np2TBdelete").width() > mWidth) { np2TB_toggle("np2TBdelete"); } } else { if($("#np2TBpromote").width() > mWidth) { np2TB_toggle("np2TBpromote"); } } if($("#" + linkName).width() =3D=3D mWidth) { $("#" + linkName).width("374"); $("#" + linkName).css("left", shift + "px"); $("#" + linkName + " tr.np2TB_header = td.np2TB_tl").toggleClass("np2TB_hide"); $("#" + linkName + " tr.np2TB_header = td.np2TB_tr").toggleClass("np2TB_hide"); $("#" + linkName + " tr = td.np2TB_buttonBox").toggleClass("np2TB_borderBottom"); $("#" + linkName + " = tr.np2TB_topRow").children().toggleClass("np2TB_hide"); $("#" + linkName + " = tr.np2TB_contentRow").children().toggleClass("np2TB_hide"); $("#" + linkName).parent().css("z-index", "3"); } else { $("#" + linkName).width(mWidth); $("#" + linkName).css("left", "0"); $("#" + linkName + " tr.np2TB_header = td.np2TB_tl").toggleClass("np2TB_hide"); $("#" + linkName + " tr.np2TB_header = td.np2TB_tr").toggleClass("np2TB_hide"); $("#" + linkName + " tr = td.np2TB_buttonBox").toggleClass("np2TB_borderBottom"); $("#" + linkName + " = tr.np2TB_topRow").children().toggleClass("np2TB_hide"); $("#" + linkName + " = tr.np2TB_contentRow").children().toggleClass("np2TB_hide"); $("#" + linkName).parent().css("z-index", "4"); } return false; } /* For Toolbox display: adjust css for browser: */ $(document).ready(function() { if($.browser.opera) { $("#np2TBdelete").css("width", "155px"); $("#np2TBpromote").css("width", "155px"); } else if($.browser.safari) { $("#np2TBdelete").css("width", "153px"); $("#np2TBpromote").css("width", "153px"); } }); ------=_NextPart_000_007D_01CCF544.4A000BC0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.thewhig.com/js/hover.js =EF=BB=BFvar menu_obj =3D null; function checkHover() { if (menu_obj) { menu_obj.find('ul').css('display', 'none');=09 } //if } //checkHover $(document).ready(function() { $('.Menu > li').hover(function() { if (menu_obj) { menu_obj.find('ul').css('display', 'none'); menu_obj =3D null; } //if =09 $(this).find('ul').css('display', 'block'); }, function() { menu_obj =3D $(this); setTimeout( "checkHover()", 100); }); $('.subMenu > li').hover(function() { //$(this).css('background-color', 'Black'); $(this).find('a').css('color', 'White'); }, function() { $(this).css('background-color', ''); $(this).find('a').css('color', ''); }); }); ------=_NextPart_000_007D_01CCF544.4A000BC0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.thewhig.com/js/jquery.lightbox-0.5.js /** * jQuery lightBox plugin * This jQuery plugin was inspired and based on Lightbox 2 by Lokesh = Dhakar (http://www.huddletogether.com/projects/lightbox2/) * and adapted to me for use like a plugin from jQuery. * @name jquery-lightbox-0.5.js * @author Leandro Vieira Pinho - http://leandrovieira.com * @version 0.5 * @date April 11, 2008 * @category jQuery plugin * @copyright (c) 2008 Leandro Vieira Pinho (leandrovieira.com) * @license CC Attribution-No Derivative Works 2.5 Brazil - = http://creativecommons.org/licenses/by-nd/2.5/br/deed.en_US * @example Visit http://leandrovieira.com/projects/jquery/lightbox/ for = more informations about this jQuery plugin */ // Offering a Custom Alias suport - More info: = http://docs.jquery.com/Plugins/Authoring#Custom_Alias (function($) { /** * $ is an alias to jQuery object * */ $.fn.lightBox =3D function(settings) { // Settings to configure the jQuery lightBox plugin how you like settings =3D jQuery.extend({ // Configuration related to overlay overlayBgColor: '#000', // (string) Background color to overlay; = inform a hexadecimal value like: #RRGGBB. Where RR, GG, and BB are the = hexadecimal values for the red, green, and blue values of the color. overlayOpacity: 0.8, // (integer) Opacity value to overlay; = inform: 0.X. Where X are number from 0 to 9 // Configuration related to navigation fixedNavigation: false, // (boolean) Boolean that informs if the = navigation (next and prev button) will be fixed or not in the interface. // Configuration related to images imageLoading: '/images/lightbox/lightbox-ico-loading.gif', // = (string) Path and the name of the loading icon imageBtnPrev: '/images/lightbox/lightbox-btn-prev.gif', // = (string) Path and the name of the prev button image imageBtnNext: '/images/lightbox/lightbox-btn-next.gif', // = (string) Path and the name of the next button image imageBtnClose: '/images/lightbox/lightbox-btn-close.gif', // = (string) Path and the name of the close btn imageBlank: '/images/lightbox/lightbox-blank.gif', // (string) = Path and the name of a blank image (one pixel) // Configuration related to container image box containerBorderSize: 10, // (integer) If you adjust the padding in = the CSS for the container, #lightbox-container-image-box, you will need = to update this value containerResizeSpeed: 400, // (integer) Specify the resize duration = of container image. These number are miliseconds. 400 is default. // Configuration related to texts in caption. For example: Image 2 of = 8. You can alter either "Image" and "of" texts. txtImage: 'Image', // (string) Specify text "Image" txtOf: 'of', // (string) Specify text "of" // Configuration related to keyboard navigation keyToClose: 'c', // (string) (c =3D close) Letter to close the = jQuery lightBox interface. Beyond this letter, the letter X and the = SCAPE key is used to. keyToPrev: 'p', // (string) (p =3D previous) Letter to show the = previous image keyToNext: 'n', // (string) (n =3D next) Letter to show the next = image. // Don=B4t alter these variables in any way imageArray: [], activeImage: 0 },settings); // Caching the jQuery object with all elements matched var jQueryMatchedObj =3D this; // This, in this context, refer to = jQuery object /** * Initializing the plugin calling the start function * * @return boolean false */ function _initialize() { _start(this,jQueryMatchedObj); // This, in this context, refer to = object (link) which the user have clicked return false; // Avoid the browser following the link } /** * Start the jQuery lightBox plugin * * @param object objClicked The object (link) whick the user have = clicked * @param object jQueryMatchedObj The jQuery object with all elements = matched */ function _start(objClicked,jQueryMatchedObj) { // Hime some elements to avoid conflict with overlay in IE. These = elements appear above the overlay. $('embed, object, select').css({ 'visibility' : 'hidden' }); // Call the function to create the markup structure; style some = elements; assign events in some elements. _set_interface(); // Unset total images in imageArray settings.imageArray.length =3D 0; // Unset image active information settings.activeImage =3D 0; // We have an image set? Or just an image? Let=B4s see it. if ( jQueryMatchedObj.length =3D=3D 1 ) { settings.imageArray.push(new = Array(objClicked.getAttribute('href'),objClicked.getAttribute('title')));= } else { // Add an Array (as many as we have), with href and title atributes, = inside the Array that storage the images references =09 for ( var i =3D 0; i < jQueryMatchedObj.length; i++ ) { settings.imageArray.push(new = Array(jQueryMatchedObj[i].getAttribute('href'),jQueryMatchedObj[i].getAtt= ribute('title'))); } } while ( settings.imageArray[settings.activeImage][0] !=3D = objClicked.getAttribute('href') ) { settings.activeImage++; } // Call the function that prepares image exibition _set_image_to_view(); } /** * Create the jQuery lightBox plugin interface * * The HTML markup will be like that:

* */ function _set_interface() { // Apply the HTML markup into body tag $('body').append('

Engineering relief

By Danielle VandenBrink/The = Whig-Standard

Posted 12 hours ago

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